LU81565A1 - Nouvelles imidazoquinoxalines et leurs sels,leur procede de preparation,leur application a titre de medicaments et les compositions pharmaceutiques les renfermant - Google Patents
Nouvelles imidazoquinoxalines et leurs sels,leur procede de preparation,leur application a titre de medicaments et les compositions pharmaceutiques les renfermant Download PDFInfo
- Publication number
- LU81565A1 LU81565A1 LU81565A LU81565A LU81565A1 LU 81565 A1 LU81565 A1 LU 81565A1 LU 81565 A LU81565 A LU 81565A LU 81565 A LU81565 A LU 81565A LU 81565 A1 LU81565 A1 LU 81565A1
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- LU
- Luxembourg
- Prior art keywords
- formula
- quinoxaline
- acid
- salts
- product
- Prior art date
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- 150000003839 salts Chemical class 0.000 title claims description 36
- 239000003814 drug Substances 0.000 title claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 11
- 238000002360 preparation method Methods 0.000 title claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 47
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
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- 239000002253 acid Substances 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 13
- UPUZGXILYFKSGE-UHFFFAOYSA-N quinoxaline-2-carboxylic acid Chemical compound C1=CC=CC2=NC(C(=O)O)=CN=C21 UPUZGXILYFKSGE-UHFFFAOYSA-N 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- YELMWJNXDALKFE-UHFFFAOYSA-N 3h-imidazo[4,5-f]quinoxaline Chemical class N1=CC=NC2=C(NC=N3)C3=CC=C21 YELMWJNXDALKFE-UHFFFAOYSA-N 0.000 claims description 6
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims description 6
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
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- 125000005843 halogen group Chemical group 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- FFQDAHCLGUATRD-UHFFFAOYSA-N 8-chloroimidazo[1,2-a]quinoxaline-2-carboxylic acid Chemical compound C1=C(Cl)C=C2N3C=C(C(=O)O)N=C3C=NC2=C1 FFQDAHCLGUATRD-UHFFFAOYSA-N 0.000 claims description 2
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- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- YOWAEZWWQFSEJD-UHFFFAOYSA-N quinoxalin-2-amine Chemical compound C1=CC=CC2=NC(N)=CN=C21 YOWAEZWWQFSEJD-UHFFFAOYSA-N 0.000 description 1
- 150000003252 quinoxalines Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000029305 taxis Effects 0.000 description 1
- 101150068774 thyX gene Proteins 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7831934 | 1978-08-02 | ||
| GB7831934 | 1978-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU81565A1 true LU81565A1 (fr) | 1980-04-21 |
Family
ID=10498811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU81565A LU81565A1 (fr) | 1978-08-02 | 1979-08-01 | Nouvelles imidazoquinoxalines et leurs sels,leur procede de preparation,leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4254123A (en]) |
| JP (1) | JPS5522682A (en]) |
| AT (1) | AT370734B (en]) |
| AU (1) | AU528158B2 (en]) |
| BE (1) | BE878028A (en]) |
| CA (1) | CA1121353A (en]) |
| CH (1) | CH641806A5 (en]) |
| DE (1) | DE2931418A1 (en]) |
| DK (1) | DK324979A (en]) |
| ES (1) | ES483039A1 (en]) |
| FR (1) | FR2432520A1 (en]) |
| HU (1) | HU178089B (en]) |
| IL (1) | IL57785A (en]) |
| IT (1) | IT1162359B (en]) |
| LU (1) | LU81565A1 (en]) |
| NL (1) | NL7905956A (en]) |
| PT (1) | PT70013A (en]) |
| SE (1) | SE439308B (en]) |
| ZA (1) | ZA793843B (en]) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS582508A (ja) * | 1981-06-26 | 1983-01-08 | Central Res Inst Of Electric Power Ind | 接触燃焼による加熱方法 |
| IL66835A (en) * | 1981-09-24 | 1988-05-31 | Roussel Uclaf | 1,4-disubstituted(1,2,4)triazolo(4,3-alpha)quinazolin-5(4h)-one derivatives and their salts,their preparation and pharmaceutical compositions containing them |
| US4472401A (en) * | 1981-11-27 | 1984-09-18 | Roussel Uclaf | Pyrimido-quinoxalines having antiallergic properties |
| US4510143A (en) * | 1982-02-17 | 1985-04-09 | Roussel Uclaf | Antiallergic pyrimido[1,2-a]quinoxalin-2-carboxylic acid derivatives |
| SE462338B (sv) * | 1982-04-28 | 1990-06-11 | Roussel Uclaf | Nya imidazo /1,2-a/ kinoxaliner och deras salter, foerfarande foer framstaellning daerav samt farmaceutiska kompositioner innehaallande densamma |
| JPS60144557A (ja) * | 1983-12-30 | 1985-07-30 | Susumu Nakagawa | 湯沸し器における湯沸し熱源たるセラミツク発熱体の発熱方法 |
| JPS6367711U (en]) * | 1986-10-23 | 1988-05-07 | ||
| JP3147902B2 (ja) * | 1991-06-14 | 2001-03-19 | ファルマシア・アンド・アップジョン・カンパニー | イミダゾ〔１，５−ａ〕キノキサリン |
| AU9651198A (en) | 1997-11-11 | 1999-05-31 | Ono Pharmaceutical Co. Ltd. | Fused pyrazine compounds |
| CA2717171A1 (en) * | 2008-03-04 | 2009-09-11 | Schering Corporation | Amino-quinoxaline and amino-quinoline compounds for use as adenosine a2a receptor antagonists |
| WO2017037604A1 (en) * | 2015-08-28 | 2017-03-09 | Bheema Rao Paraselli | Novel fyn kinase inhibitors |
| CN111732493B (zh) * | 2017-01-16 | 2023-01-24 | 宜昌尚诺德生物医药科技有限公司 | 一种芳胺化合物的合成工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1347493A (en) * | 1971-02-11 | 1974-02-27 | Aspro Nicholas Ltd | Benzazine derivatives |
| GB1551166A (en) * | 1976-03-22 | 1979-08-22 | Squibb & Sons Inc | Pyrazolo (1,5-a)quinoxaline-3-carboxylic acid and derivatives thereof |
| US4145419A (en) * | 1976-05-21 | 1979-03-20 | Roussel Uclaf | Novel imidazobenzoxazines |
| GB1538479A (en) * | 1976-05-21 | 1979-01-17 | Roussel Labor Ltd | Imidazobenzoxazines |
| US4075343A (en) * | 1976-09-13 | 1978-02-21 | Pfizer Inc. | Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof |
| US4160097A (en) * | 1977-01-07 | 1979-07-03 | Westwind Pharmaceuticals, Inc. | 1-(2-Phenylureylene)imidazoles |
| GB1576077A (en) * | 1977-04-13 | 1980-10-01 | Roussel Lab Ltd | 4,5-dihydro-4-oxophyrrolo(1,2-)-quinoxaline-2-carboxylic acids and derivatives |
-
1979
- 1979-07-10 SE SE7906011A patent/SE439308B/sv not_active IP Right Cessation
- 1979-07-12 IL IL57785A patent/IL57785A/xx unknown
- 1979-07-13 FR FR7918216A patent/FR2432520A1/fr active Granted
- 1979-07-25 AT AT0514379A patent/AT370734B/de not_active IP Right Cessation
- 1979-07-26 ZA ZA00793843A patent/ZA793843B/xx unknown
- 1979-07-30 US US06/061,626 patent/US4254123A/en not_active Expired - Lifetime
- 1979-07-31 JP JP9686979A patent/JPS5522682A/ja active Granted
- 1979-07-31 HU HU79RO1033A patent/HU178089B/hu not_active IP Right Cessation
- 1979-08-01 AU AU49462/79A patent/AU528158B2/en not_active Ceased
- 1979-08-01 LU LU81565A patent/LU81565A1/fr unknown
- 1979-08-01 CA CA000333014A patent/CA1121353A/fr not_active Expired
- 1979-08-01 IT IT49927/79A patent/IT1162359B/it active
- 1979-08-01 ES ES483039A patent/ES483039A1/es not_active Expired
- 1979-08-01 DK DK324979A patent/DK324979A/da not_active Application Discontinuation
- 1979-08-01 PT PT70013A patent/PT70013A/pt unknown
- 1979-08-01 BE BE0/196568A patent/BE878028A/fr not_active IP Right Cessation
- 1979-08-02 CH CH710579A patent/CH641806A5/fr not_active IP Right Cessation
- 1979-08-02 DE DE19792931418 patent/DE2931418A1/de active Granted
- 1979-08-02 NL NL7905956A patent/NL7905956A/nl not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES483039A1 (es) | 1980-09-01 |
| PT70013A (fr) | 1979-09-01 |
| AU4946279A (en) | 1980-02-07 |
| SE439308B (sv) | 1985-06-10 |
| BE878028A (fr) | 1980-02-01 |
| IL57785A0 (en) | 1979-11-30 |
| ATA514379A (de) | 1982-09-15 |
| AU528158B2 (en) | 1983-04-14 |
| SE7906011L (sv) | 1980-02-03 |
| JPH0141637B2 (en]) | 1989-09-06 |
| DK324979A (da) | 1980-02-03 |
| IT1162359B (it) | 1987-03-25 |
| IT7949927A0 (it) | 1979-08-01 |
| US4254123A (en) | 1981-03-03 |
| DE2931418C2 (en]) | 1989-06-29 |
| DE2931418A1 (de) | 1980-02-28 |
| ZA793843B (en) | 1980-09-24 |
| JPS5522682A (en) | 1980-02-18 |
| HU178089B (en) | 1982-03-28 |
| NL7905956A (nl) | 1980-02-05 |
| CA1121353A (fr) | 1982-04-06 |
| IL57785A (en) | 1984-01-31 |
| FR2432520B1 (en]) | 1982-11-12 |
| AT370734B (de) | 1983-04-25 |
| CH641806A5 (fr) | 1984-03-15 |
| FR2432520A1 (fr) | 1980-02-29 |
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